Research Paper Volume 15, Issue 16 pp 7909—7921

Figure 2. Circadian transcriptome of the aged pancreas. (A) Examples of circadian profiles of genes that are rhythmic in both young and old mice (Arntl, Per2, Tef), only in old mice (Col1a1, Cdh11), and only in young mice (Cpsf3). (B) Enriched molecular pathways corresponding to rhythmic genes in young and old mice. (C) Peak time maps of all oscillating genes from young and old mice. Each dot represents the peak time of 10 significantly rhythmic genes. Enriched pathways corresponding to each time point are also shown. (D) Clock correlation distance (CCD) of 12 core clock genes from young and old mice pancreas.