Research Paper Volume 15, Issue 16 pp 7974—7996

Figure 2. Unsupervised cluster analysis was performed on the TCGA-KIRC dataset to group patients based on the expression level of CXCL genes. The results show the distribution of four clusters, CDF plot (A-i) and delta area plot (A-ii) were presented. The overall survival (OS) of patients in each cluster was analyzed using KM (B). The expression of CXCL genes was analyzed between the clusters (C), and the immune components of the clusters were analyzed using the xCELL and TIMER methods (D, E). The immune checkpoints’ expression was also analyzed between the C3 and C4 clusters (F). The mutation condition of patients in the C3 and C4 clusters was also analyzed (G, H), as well as the correlation between VHL/RBPM1 mutation and the expression of CXCL genes (I).