Research Paper Volume 15, Issue 14 pp 7278—7307
Active components and molecular mechanisms of Sagacious Confucius’ Pillow Elixir to treat cognitive impairment based on systems pharmacology
Figure 7. Effects of SCPE on CI in model mice measured using the Morris water maze test. (A, B) Acquisition tests. (A) Goal/escape latency was measured twice per day. (B) Total swimming distance measured twice per day. SCPE was administered orally at doses of 2.3 g/kg, 4.6 g/kg and 9.2 g/kg. The MWM test was performed 2 h after oral administration. The data are presented as means ± SD (n = 10). *P < 0.05 and **P < 0.01 compared with the control group. #P < 0.05 compared with the model group. (C, D) Probe test. (C) Time spent in the target/first quadrant; (D) Number of platform crossings. The data are presented as the means ± SD (n = 10). **P < 0.01 compared with the control group. #P < 0.05 compared with the model group. (E) Real swimming tracks of mice in each group in the MWM.