Research Paper Volume 15, Issue 14 pp 7278—7307
Active components and molecular mechanisms of Sagacious Confucius’ Pillow Elixir to treat cognitive impairment based on systems pharmacology
Figure 12. Expression of proteins related to PI3K/AKT/mTOR signaling in the hippocampus. (A) Western blot bands showing the levels of the p-PI3Kp85, PI3Kp85, p-AKT, AKT, p-mTOR, mTOR, LC3-II, LC3-I, P62, and Tau proteins in the hippocampus. (B–G) Quantification of the p-PI3Kp85/PI3Kp85, p-AKT/AKT, p-mTOR/mTOR, LC3-II/LC3-I P62, and Tau levels in the hippocampal tissue. The data are presented as means ± SD (n = 3). **P < 0.01 compared with the model group; ##P < 0.01 and #P < 0.01 compared with the 2.3 g/kg or 4.6 g/kg group. Abbreviation: ns: not significant.