Research Paper Volume 15, Issue 14 pp 6690—6709
Parallel shift of DNA methylation and gene expression toward the mean in mouse spleen with aging
Figure 2. Increase in inter-individual methylation variations in older spleens. (A) Chromosomal variation in methylation levels of genomic categories. The mean methylation level of each genomic category was determined for each chromosome and shown in the line chart. Error bars represent standard deviation. (B) Age-related increase in inter-individual methylation heterogeneity. It shows the distribution of the variance coefficient (CV) of methylation levels across 19 chromosomes (excluding sex chromosomes) for different genomic structures/functions within the same age group. The points on the box plot represent the CV values of each chromosome. The p-values between successive age pairs are shown and were calculated using a paired-sample t-test.