Figure 3. Hub genes and the biology network for differentially expressed IRGs in GSE32269. (A) A total of 197 IRGs were used for drawing the PPI network. Red indicated up-regulated, and green indicated down-regulated IRGs in bone metastasis tissues of prostate cancer. (B, C) Confirmation of the top 20 IRGs and establishment of the PPI network by degree and betweenness topological methods. (D) Venn diagram to determine 12 hub IRGs.