Figure 8. Construction and evaluation of the 6-gene signature. (A) The multivariate Cox risk model of 6 genes. (B) OS curves of the two risk subgroups (HR = 1.9, p-value < 0.001). (C) The distribution of risk scores, survival times and outcomes of LUSC patients. (D) Receiver operating characteristic (ROC) curves for 2-, 4- and 6-year of TCGA-LUSC cohort. (E, F) Univariate and multivariate Cox regression analyses of the risk model and other clinic-pathological factors. (G–I) External validation in GEO database (GSE30219, GSE157011, and GSE3141).