Research Paper Volume 15, Issue 14 pp 6905—6920

Figure 8. exo-PD acts on intestinal cells via the PI3K-AKT pathway as determined by phosphorylated protein profiling. (A, B) Differential proteins and differential loci derived from proteomic and phosphorylated proteomic modification assays. (C) STING protein interactions. Red represents phosphorylation regulation, blue represents PI3K-AKT signalling pathway and green represents intracellular membrane-bound organelles. (D) Effect of PD, exo and ex-PD on protein expression of PI3K/AKT and γ-H2AX in mouse intestine after 24 h of IR. (E) Western blot of IL-1α and IL-6 in mouse intestine after exo-PD treatment. (F) Expression of PI3K and p-AKT after treatment with different conditions following the addition of AKT inhibitors.