Research Paper Volume 15, Issue 14 pp 6834—6847
Oxidized phospholipids facilitate calcific aortic valve disease by elevating ATF4 through the PERK/eIF2α axis
Figure 2. Abundant expression of ATF4 in CAVD samples. (A) A heat map of differentially expressed gene expression in 2 normal samples and 2 CAVD samples in the GSE159832 dataset. (B) Venn diagram of the differentially expressed genes in the GSE159832 dataset, CAVD-related transcription factors from the JASPAR database, and the top 1500 CAVD-related genes from the GeneCards database. (C) A box plot of ATF4 expression in 2 normal samples (blue box) and 2 CAVD samples (red box) in the GSE159832 dataset. p = 0.0314. *p < 0.05.