Research Paper Volume 15, Issue 13 pp 6545—6576
Comprehensive prognostic and immunological analysis of Ubiquitin Specific Peptidase 28 in pan-cancers and identification of its role in hepatocellular carcinoma cell lines
Figure 2. Clinical landscape of USP28 expression levels in pan-cancer. (A) The difference in USP28 expression between tumor and normal tissues in different cancers through TCGA and GTEx datasets. (B) The immunofluorescence images of the USP28 protein, nucleus, endoplasmic reticulum (ER), microtubules, and the merged images in U251-MG, U2-OS, and A431 cell lines. (C) Based on the CPTAC dataset, the expression level of USP28 phosphoprotein, including Y1117, S1115, S896, S113, and S495, between normal tissue and primary tissue of selected tumors via the UALCAN. (D) The correlation of USP28 expression levels with pathological stages (stage I stage II, stage III, stage IV) was analyzed using the TCGA dataset. Log2 (TPM+1) was applied for the log scale. (E) PPI network to identify the USP28-interacting proteins using the GeneMANIA database. *p < 0.05; ** p < 0.01; *** p < 0.001.