Figure 2. Cuprotosis modification patterns identified with K-means clustering based on cuprotosis genes. (A) PPI network showing the interactions of the 12 cuprotosis-related genes. (B) The interactions of the 12 cuprotosis-related genes in meta cohort. (C) Heat map of unsupervised clustering analysis. (D) PCA of different cuprotosis subtypes. (E) Kaplan-Meier analysis of overall survival for different cuprotosis subtypes. (F) Box plot of cuprotosis-related gene expression in different cuprotosis subtypes in AML patients (*P < 0.05, **P < 0.01, ***P < 0.001).