Senescence-related gene c-Myc affects bladder cancer cell senescence by interacting with HSP90B1 to regulate cisplatin sensitivity

Yaxuan Wang; Haixia Zhu; Haifei Xu; Yifan Qiu; Yonghong Zhu; Xiaolin Wang

doi:doi:10.18632/aging.204863

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Research Paper Volume 15, Issue 15 pp 7408—7423

Senescence-related gene c-Myc affects bladder cancer cell senescence by interacting with HSP90B1 to regulate cisplatin sensitivity

Figure 5. HSP90B1 is significantly associated with cisplatin chemotherapy in bladder cancer. (A) Interaction network map of c-Myc with other genes. (B) Forest plot of c-Myc interacting genes with prognostic significance in bladder cancer. (C) c-Myc interacting genes with prognostic value expressed in bladder cancer and normal bladder tissues. (D) Five key genes with cisplatin IC50 score for correlation. (E) Correlation of HSP90B1 with chemotherapeutic agents in bladder cancer.