Research Paper Volume 15, Issue 13 pp 6400—6428

Figure 4. Correlation among clinicopathological classifications and CDM signature risk scores. (A) Boxplot. Correlation between tumour stage and risk-CDM score in TCGA-COAD cohort. Pink represents I stage, green represents II stage, Cyan represents III stage and violet represents IV stage. (B) Boxplot. Correlation between depth of tumor invasion (T) and risk-CDM score in TCGA-COAD cohort. Pink represents T1, green represents T2, cyan represents T3 and violet represents T4. (C) Boxplot. Correlation between lymph node metastasis (N) and risk-CDM score in TCGA-COAD cohort. Pink represents N0 (not metastasis), green represents N1 (1-3 regional lymph node metastases) and blue represents N2 (4 or more regional lymph node metastases). (D) Boxplot. Correlation between tumour stage and risk-CDM score in GSE17536 cohort. Pink represents I stage, green represents II stage, Cyan represents III stage and violet represents IV stage. (E) Boxplot. Correlation between grade and risk-CDM score in GSE17536 cohort. Pink represents G1 (good), green represents G2 (moderate) and blue represents G3 (poor). (F) Microsatellite stability histogram. MSS (blue), MSI-L (red) and MSI-H (orange) of High/Low risk group samples in TCGA-COAD cohort. (G) Boxplot. Correlation between microsatellite stability and risk-CDM score in TCGA-COAD samples. MSS (blue), MSI-L (red) and MSI-H (orange).