Research Paper Volume 15, Issue 13 pp 6380—6399
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway
Figure 8. DSC2 inhibited the viability of MGC-803 cells through suppressing PI3K/AKT/mTOR signaling pathway. Effect of DSC2 on the viability of GC cells in the presence of LY294002 and IGF1 was determined by Caspase-3 activity assay (A), Sperm DNA fragmentation assay (B) and MTT assay (C). Data are presented as mean ± SEM from three separate experiments. **p<0.01 and ***p<0.001 vs. Lenti-NC or Lenti-DSC2 group. (D, E) The levels of γ-catenin both in cells and in the nucleus among MGC-803 cells that treated with LY294002 or IGF1, were tested by Western blot assay. The data are represented as mean ± SEM, n=3. ***p<0.001 vs. Lenti-NC.