Research Paper Volume 15, Issue 13 pp 6380—6399
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway
Figure 3. Silencing the DSC2 gene promoted viability of GC cells in vitro. After being transfected with siDSC2(1+2), the viability of cells was determined by colony formation assay (A, in MGC-803 cells), MTT assay, Caspase-3 activity assay and sperm DNA fragmentation assay (B–D, in MGC-803 and SGC-7901 cells). (E, F) The expression of BCL-2 and Cyto-C were determined by Western blot assay. Data are presented as mean ± SEM from three separate experiments. **p<0.01 and ***p<0.001 vs. BC. ##p<0.01 and ###p<0.001 vs. Si-NC group. Si-NC: Small interfering negative control group.