Research Paper Volume 15, Issue 13 pp 6380—6399
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway
Figure 2. DSC2 suppressed viability of GC cells in vitro. After stably expressing DSC2 gene, the viability of cells was determined by colony formation assay (A, in MGC-803 cells), MTT assay, Caspase-3 activity assay and sperm DNA fragmentation assay (B–D, in MGC-803 and SGC-7901 cells). (E, F) The expression of BCL-2 and Cyto-C were determined by Western blot assay. Data are presented as mean ± SEM from three separate experiments. **p<0.01 and ***p<0.001 vs. BC. ##p<0.01 and ###p<0.001 vs. Lenti-NC group. BC: blank control group, Lenti-NC: lentivirus negative control group.