Research Paper Volume 15, Issue 13 pp 6264—6291

Figure 8. Immunological characteristics and drug sensitivities between different RiskScore groups. (A) The difference in “T cell inflamed GEP score” among various molecular subtypes. (B) The difference in “response to IFN-γ” among various molecular subtypes. (C) The difference in “Cytolytic activity” among various molecular subtypes. (D) Expression differences of immune checkpoint-associated genes among various molecular subtypes. (E) A box plot of the estimated IC₅₀ values for temozolomide, bleomycin, cisplatin, cyclopamine, A-443654, AZD6482, and GDC0941 in TCGA-LGG. ^**P < 0.01; ^****P < 0.0001. Abbreviations: ns: no significance; GEP: gene expression profile; IFN: interferon; TPM: transcripts per million; IC₅₀: half-maximal inhibitory concentration; TCGA: The Cancer Genome Atlas; LGG: low-grade glioma.