Research Paper Volume 15, Issue 13 pp 6264—6291

Figure 4. Immunological characteristics scores characterizing the effect of immunotherapy in different subtypes. (A) Expression differences of immune checkpoint-related genes among molecular subtypes. (B) Variation in response to IFN-γ among molecular subtypes. (C) The difference in expression of IFNG gene among molecular subtypes. (D) Differences in “Cytolytic activity” among molecular subtypes. (E) Variation in the T cell inflamed GEP score among molecular subtypes. (F) A box plot of the estimated IC₅₀ values for temozolomide, bleomycin, cisplatin, cyclopamine, A-443654, AZD6482, and GDC0941 in TCGA-LGG. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001; ^****P < 0.0001. Abbreviations: ns: no significance; TPM: transcripts per million; IFN: interferon; GEP: gene expression profile; IC₅₀: half-maximal inhibitory concentration; TCGA: The Cancer Genome Atlas; LGG: low-grade glioma.