Research Paper Volume 15, Issue 13 pp 6264—6291

Figure 1. Molecular subtyping of LGG based on NK cell-related genes. (A) Univariate Cox forest plot of NK cell-related genes in the TCGA-LGG cohort. (B) Multivariate Cox forest plot of NK cell-related genes in the CGGA-LGG cohort. (C) CDF curve of samples in the TCGA-LGG cohort. (D) CDF delta area curve of TCGA-LGG cohort samples area curve, Delta area curve of consensus clustering indicated the relative variation in the area under the CDF curve for each category number k in comparison with k−1. The vertical axis represents the relative change in area under the CDF curve, the horizontal axis represents the category number k. (E) A heat map of sample clustering at consensus k = 4. (F) K-M survival curves showing the prognosis of the four subtypes in the TCGA-LGG cohort. (G) K-M survival curves for the prognosis of the four subtypes in the CGGA cohort. (H) A heat map showing the expression of prognostically significant NK cell-related genes in various subtypes in TCGA-LGG. (I) A heat map of the expression of prognostically significant NK cell-associated genes in various subtypes in CGGA. Abbreviations: CDF: cumulative distribution function; expr: expression; LGG: low-grade glioma; NK: natural killer; TCGA: The Cancer Genome Atlas; CGGA: Chinese Glioma Genome Atlas; K-M: Kaplan-Meier.