Review Volume 15, Issue 12 pp 5917—5950

Figure 2. Summary map of common biological mechanisms of depression and obesity. Note: IL-6, Interleukin-6; IL-1β, Interleukin-1β; TNF-α, Tumor necrosis factor-α; CCL2, C-C motif chemokine ligand 2; CRP, C-reactive protein; PGE2, prostaglandin E2; IL-10, Interleukin-10; TGF-β, transforming growth factor-beta; ARC, arcuate nucleus of the hypothalamus; POMC, pro-opiomelanocortin; AGRP, agonist peptide-related peptide; NLRP3, NOD-like receptor family pyrin domain containing 3; BDNF. brain derived neurotrophic factor; Iba-1, ionized calcium binding adapter molecule-1; GFAP, glial fibrillary acidic protein; SCFAs, short-chain fatty acids; LTP long-term potentiation, LTD, long-term depression; mPFC, medial prefrontal cortex; mTOR, mechanistic target of rapamycin; AMPK, AMP-activated protein kinase; TrkB, tyrosine kinase receptor B; PI3K, phosphatidylinositol 3-kinase; AKT, protein kinase B; MEK, MAPK/extracellular signal-regulated kinase; MAPK, mitogen-activated protein kinases; ERK, extracellular signal-regulated kinase; CRH, corticotropin-releasing hormone; AVP, arginine vasopressin; ACTH, adrenocorticotropic hormone; NEGR1, neuronal growth regulator 1; CADM2, Cell adhesion molecule 2; PMAIP1, phorbol-12-myristate-13-acetate-induced protein 1; PARK2, E3 ubiquitin-protein ligase parkin; FTO, Fat mass and obesity-associated gene; GABA, gamma-aminobutyric acid; MC4R, melanocortin 4 receptor; dBNST, bed nucleus of the stria terminus.