Review Volume 15, Issue 12 pp 5917—5950
Shared biological mechanisms of depression and obesity: focus on adipokines and lipokines
Figure 1. Overview of the mechanisms underlying the co-pathogenesis of depression and obesity: based on adipokines and lipokines. In the body, there are many kinds of adipocytes and different adipocytes can selectively release related adipokines and lipokines. Abnormal secretion of adipokines and lipokines plays a crucial role in obesity and depression and may be related to increased inflammatory response, gut microbiota disturbance, neuroplasticity, dysfunction of HPA as well as GBA/microbiota-GBA disturbance. Note: HPA axis, hypothalamic-pituitary-adrenal axis; GBA, gut-brain-axis; PAI-1, Plasminogen activator inhibitor type 1; MCP-1, Monocyte chemoattractant protein-1; RBP4, Retinol Binding Protein 4; FABP4, fatty acid-binding protein 4; IL-6, Interleukin 6; Nrg4, Neuregulin 4; FAHFAs, fatty acid esters of hydroxy fatty acids; 12,13-diHOME, 12,13-dihydroxy-(9Z)-octadecenoic acid.