Research Paper Volume 15, Issue 12 pp 5854—5872
iPSC-derived exosomes promote angiogenesis in naturally aged mice
Figure 4. Treatment with iPSC-derived exosomes significantly decreased p53 and P16 expression levels in organs of old mice. Western blot images of p53 and p16 expression in heart, liver, spleen, lung, kidney, brain, skin, and muscle of mice in different treatment groups, and the quantification of the western blot results. β-actin was used as an internal control. Young: untreated young mice; young + exo: young mice pre-treated with iPSC-derived exosomes via tail vein injection; Old: untreated old mice; Old + exo: old mice pre-treated with iPSC-derived exosomes via tail vein injection. iPSCs, induced pluripotent stem cells; exo, exosomes.