Research Paper Volume 15, Issue 12 pp 5798—5825

Figure 14. Identification and validation of the 6-gene risk signature. The risk score distribution, the survival status and overall survival time of patients and the expression of the six TRIM genes in testing (A) and validation (B) cohorts. Kaplan-Meier survival analysis in testing (C) and validation (D) cohorts suggested that high-risk group had poor OS than low risk group. Time-dependent ROC curves of the gene signature for predicting 1-year, 2-year, and 3-year overall survival in testing (E) and validation (F) cohorts. LASSO regression of the eight TRIM candidates (G). Cross-validation for tuning the parameter selection in the LASSO regression (H). LASSO, Least absolute shrinkage and selection operator.