Research Paper Volume 15, Issue 13 pp 6225—6254

Figure 6. Immune-related analysis in the TCGA and IMvigor210 cohorts. (A) Difference analysis of immune signatures and four types of TME-related scores between high and low-risk groups in the TCGA cohort. (B) The difference in infiltration level of immune cells between high and low-risk groups. (C) Differential expression of six well-known ICPs between high and low-risk groups. (D) The difference in risk score between high and low-risk groups was stratified according to response to immunotherapy. (E) The difference in the distribution of responders and non-responders between the two risk groups. (F) The subgroup map predicted the response to ICB therapy between the two risk groups. (G) ROC curves verified the accuracy of the risk score in predicting the OS for patients in the IMvigor210 cohort. (H) The K-M survival curves of OS in patients between the high and low-risk groups. (I) Differential expression of CD274(PDL1) between high and low-risk groups. (J, K) Differences in the distribution of patients with and without response to ICI immunotherapy between high and low-risk groups. CR, complete response; PR, partial response; SD, stable disease; PD, progressive disease. CR/PR was identified as responders, and SD/PD was identified as non-responders. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001.