Research Paper Volume 15, Issue 12 pp 5412—5425
Tumor-suppressive function and mechanism of miR-873-5p in glioblastoma: evidence based on bioinformatics analysis and experimental validation
Figure 2. miR-873-5p impairs GBM cell proliferation and invasion by targeting HMOX1. T98G cells were transfected with miR-873-5p mimic, oe-HMOX1 or in combination. (A) Western blot of HMOX1 protein in T98G cells. (B) Proliferation of T98G cells measured by CCK-8 assay. (C) Invasion of T98G cells measured by Transwell assay. (D) Western blot of the CCND1, E-cadherin, MYC, MMP-7, and N-cadherin proteins in T98G cells. *p < 0.05, compared to NC-mimic + oe-NC-transfected T98G cells. #p < 0.05, compared to miR-873-5p mimic + oe-NC-transfected T98G cells. The cell experiment was run in triplicate independently.