Research Paper Volume 15, Issue 11 pp 5190—5214
Identification of neoantigens and immunological subtypes in clear cell renal cell carcinoma for mRNA vaccine development and patient selection
Figure 7. Immune gene co-expression modules and immune hub genes for ccRCC identification and the established risk-estimating model. (A) Dendrogram of all differentially expressed genes clustered based on a dissimilarity measure (1-TOM). Clustering of samples. (B) Differential distribution of feature vectors of each module in ccRCC subtypes. (C) Forest maps of single-factor survival analysis of nine modules of ccRCC. (D–F) Risk-estimating model was established from prognostic modules and (G) their prognostic status from TCGA cohort. (H) ROC curve of risk of ccRCC patients from TCGA cohort. (I, J) Risk score of ccRCC patients treated with PD-1 and (K) their prognostic status from TCGA cohort. (L) ROC curve of risk of ccRCC patients treated with PD-1 from TCGA cohort. *padj < 0.05; **padj < 0.01; ***padj < 0.001.