Research Paper Volume 15, Issue 11 pp 5144—5163
Network medicine framework identified drug-repurposing opportunities of pharmaco-active compounds of Angelica acutiloba (Siebold & Zucc.) Kitag. for skin aging
Figure 5. The relationship between the Hub-target of AAK compounds and the development processes of skin aging. (A, B) The down-regulated expression of ABCC4, PTGER3, BCEH, HPGD, MOXD1 and up-regulated expression of AR, CXCR2, HSD17B2, ODC1, PI3, PLAU and THBS2 among hub-target by AAK; (C, D) ROC curves of ABCC4, AR, BCEH, PI3, BCHE, CXCR2, HPGD, HSD17B2 through dataset GSE192564 and GSE192565; (E) PPI analysis of 29 core genes; (F, G) ROC curves of MOXD1, ODC1, PLAU, PTGER3, THBS2 through dataset GSE192564 and GSE192565).