Research Paper Volume 15, Issue 11 pp 5144—5163
Network medicine framework identified drug-repurposing opportunities of pharmaco-active compounds of Angelica acutiloba (Siebold & Zucc.) Kitag. for skin aging
Figure 1. The similarity and congregate feature of the compounds of AAK. (A) Proteins targeted by AAK compounds were not randomly congregated in feature-specific adjacent region of human protein-protein interactome; (B) Proteins targeted by AAK formed a large connected component (LCC) consisting of 467 proteins, and multiple small subgraphs in the human interactome; (C) The results of Jaccard index (JI) among 29 AAK compounds; (D) Top (n = 20) enriched gene ontology terms (Biological Process)among all AAK compounds’ targets; (E) Protein–protein interactions of 29 AAK compounds’ targets).