Research Paper Volume 15, Issue 11 pp 5007—5031
Machine learning and single cell RNA sequencing analysis identifies regeneration-related hepatocytes and highlights a Birc5-related model for identifying cell proliferative ability
Figure 2. HdWGCNA of hepatocytes reveals the crucial roles of pink module. (A) Eight gene modules were obtained and the top huh gene were presented according to the hdWGCNA pipeline. (B) Cell proportion of hepatocyte clusters in different time points of PHx. (C) UMAP plot shows the distribution of 15 hepatocyte clusters in PHx 0h and PHx 48h. (D) Module activities in different hepatocyte clusters. The module score was estimated by hdWGCNA algorithm. (E) Expression density of the pink module in UMAP plot. The yellow indicates the highest activity score of the module in corresponding cells. (F) Violin plot displays the higher activity of pink module in PHx 48h mice. (G) Activity levels of pink module in 16 hepatocyte clusters.