Research Paper Volume 15, Issue 11 pp 4986—5006
Development of cancer-associated fibroblast-related gene signature for predicting the survival and immunotherapy response in lung adenocarcinoma
Figure 2. The construction of predictive model for overall survival based on CAFs-related genes. (A) Partial likelihood deviance of variables displayed by the Lasso regression model. The red dotted gray lines and two vertical lines represented the partial likelihood of deviance values, respectively. (B) Lasso coefficient profiles of 30 OS-related genes in TCGA training cohort. (C) Forest plot of CAFs-related risk signature (CAFRS) consisting of 7 genes identified by the multivariate Cox regression model. (D–F) Kaplan-Meier curves of patients from TCGA training, TCGA testing and GEO cohorts stratified by low- and high-risk subgroups. (G–I) Receiver operating characteristic (ROC) curves with 1-, 3-, and 5- year AUC values in the TCGA training, TCGA testing and GEO cohorts.