Research Paper Volume 15, Issue 11 pp 4906—4925
A spliceosome-associated gene signature aids in predicting prognosis and tumor microenvironment of hepatocellular carcinoma
Figure 6. Genetic alteration and protein expression analysis of six spliceosome-related genes signature in HCC. (A) The summary of genetic alterations of each spliceosome-related gene in the cBioPortal database. (B) Patients with genetic alteration have poorer overall survival probability. (C) There was no statistical difference in disease-free survival probability between the patients with genetic alteration and without genetic alteration. (D) The representative protein expression and localization of the BUB3, IGF2BP3, RBM3, ILF3, ZC3H13, and CCT3 in HCC and adjacent normal liver tissues. (E–G) The risk score was incrementally increased with increasing tumor nodular (E), TNM staging (F), and BCLC staging (G) in the training set.