Research Paper Volume 15, Issue 11 pp 4906—4925

Figure 3. The predictive value of the six-spliceosome-related gene signature was validated in two validation sets (TCGA and GSE76427 cohorts). (A, B) HCC patients were divided into high-risk and low-risk score groups based on the median risk score in the TCGA cohort (A) and GSE76427 cohort (B); HCC patients were divided into high-risk and low-risk score groups based on the median risk score; High-risk score groups had lower survival rates than patients in low-risk score groups; Patients in high-risk score groups have lower ZC3H13 mRNA expression, whereas higher RBM3, ILF3, IGF2BP3, CCT3, and BUB3 mRNA levels. (C) 1-, 3-, and 5-year time-dependent receiver operating characteristic curve of the spliceosome-related genes signature in the TCGA cohort. (D) High-risk score patients have poorer overall survival probability in the TCGA cohort. (E) 1-, 3-, and 5-year time-dependent receiver operating characteristic curve of the spliceosome-related genes signature in the GSE76427 cohort. (F) High-risk score patients have poorer overall survival probability in GSE76427 cohort.