Research Paper Volume 15, Issue 11 pp 4906—4925

Figure 2. Prognostic analysis of the six-spliceosome-related gene signature in the training set. (A) six spliceosome-related genes were identified by the Least absolute shrinkage and selection operator (LASSO) regression model according to minimum criteria. (B) The coefficient of spliceosome-related genes was calculated by LASSO regression. (C) HCC patients were divided into high-risk and low-risk score groups based on the median risk score; High-risk score groups had lower survival rates than patients in low-risk score groups; Patients in high-risk score groups has lower ZC3H13 mRNA expression, whereas higher RBM3, ILF3, IGF2BP3, CCT3, and BUB3 mRNA levels. (D) 1-, 3-, and 5-year time-dependent receiver operating characteristic curve (ROC) of the spliceosome-related genes signature in the training cohort. (E) High-risk score patients have poorer overall survival probability than patients with low-risk scores in the training set. (F) Forrest plot of the univariate and multivariate Cox regression analyses for overall survival in the training set.