Research Paper Volume 15, Issue 12 pp 5355—5380
Construction and experimental validation of a B cell-related gene signature to predict the prognosis and immunotherapeutic sensitivity in bladder cancer
Figure 7. BCRS was associated with B cells’ activation and proliferation, and served as a potential predictor to immunotherapeutic response. (A) The processes of the GSEA in the 326 B cell samples. (B, C) The negative regulation of B cells’ activation (B) and proliferation (C) was enriched in the high-BCRS B cells. (D, E) The positive regulation of B cells’ activation (D) and proliferation (E) was enriched in the low-BCRS B cells. (F, G) BCRS was negatively associated with B cells’ infiltration levels, both in the TCGA-BLCA cohort (F) and the NH cohort (G). (H) The levels of BCRS between immunotherapeutic responders and non-responders from the TCGA-BLCA cohort, IMvigor210 cohort, and GSE111636 cohort. (I) The predictive ability of BCRS to immunotherapeutic response in the TCGA-BLCA cohort, IMvigor210 cohort, and GSE111636 cohort. (J) High levels of BCRS heralded poor prognosis in the IMvigor210 cohort.