Xuebijing injection protects against sepsis-induced myocardial injury by regulating apoptosis and autophagy via mediation of PI3K/AKT/mTOR signaling pathway in rats

Cheng-Fei Bi; jia Liu; Shao-Wen Hao; Zhi-Xia Xu; Xiao Ma; Xiang-Fei Kang; Li-Shan Yang; Jun-Fei Zhang

doi:doi:10.18632/aging.204740

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Research Paper Volume 15, Issue 10 pp 4374—4390

Xuebijing injection protects against sepsis-induced myocardial injury by regulating apoptosis and autophagy via mediation of PI3K/AKT/mTOR signaling pathway in rats

Figure 4. Effects of XBJ on sepsis-mediated cardiomyocyte apoptosis at 12h, 1d, 2d, 3d and 5d after CLP. (A) Representative images show apoptosis of heart tissue was detected by TUNEL staining. (B) Representative images and relative intensity of western blot for Bax, Bcl-2, Caspase 3, Cleaved-Caspase 3, Cleaved-Caspase 9, Cytochrome C and Cleaved-PARP.