Research Paper Volume 15, Issue 9 pp 3791—3806
microRNA-497 slows esophageal cancer development and reverses chemotherapy resistance through its target QKI
Figure 2. miR-497 overexpression inhibits cell proliferation, migration, tube formation and colony formation. (A) Compared to normal esophageal HEEC cell, the expression levels of miR-497 in EC cell lines were significantly lower. (B, C) Overexpression of miR-497 greatly reduced percentages of EdU staining signals in Eca109 and Kyse30 cells. (D) Overexpression of miR-497 inhibited cell migration activities. (E) The overexpression of miR-497 attenuated tube formation activities. (F) Forced expression of miR-497 attenuated the colony formation activities in cancer cells. All data were representative of 3 independent experiments. ** indicated significant difference at p<0.01.