Research Paper Volume 15, Issue 9 pp 3635—3643

Figure 1. TIMP2 can aggravate brain water content and brain tissue damage in CIRI mice. (A) Brain water content is measured in the control group, I/R group, and I/R+TIMP2 group. Brain water content is significantly higher in the I/R group than that in the control group. Furthermore, the use of TIMP2 further increases brain water content in the I/R group. In contrast, brain water content is significantly reduced in the TIMP2-KD group. (B, C) Pathological changes in brain tissues are observed using HE staining in the control group, I/R group, and I/R+TIMP2 group. No pathological changes are observed in the control group, whereas mice in the I/R+TIMP2 group showed larger pathological changes compared with the I/R group. Conversely, the pathological area in the brain tissues of mice in the TIMP2-KD group becomes smaller. ^**P < 0.01, ^*P < 0.05.