Research Paper Volume 15, Issue 9 pp 3498—3523

A novel methionine metabolism-related signature predicts prognosis and immunotherapy response in lung adenocarcinoma

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Figure 1. Transcriptome-based expressional alterations and prognostic impacts of MRGs across multiple LUAD datasets. (A) Heatmap showing the difference of mRNA expression levels of 68 MRGs between normal and LUAD samples in 13 datasets with matched controls. The color depicts the log2-transformed fold change (Log2FC) between tumor and normal tissues. Please also refer to Supplementary Table 2. (B) Association between MRGs expression and patient prognosis across 30 LUAD datasets with survival information as determined by the Log-rank test. The color represents Zscore-transformed hazard ratio (HR) and asterisks represent the statistical p value (*p < 0.05; **p < 0.01; ***p < 0.001). Please also refer to Supplementary Table 3.