Editorial Volume 15, Issue 8 pp 2819—2821
The senescence-associated secretory phenotype induces neuroendocrine transdifferentiation
Figure 1. Cell culture supernatant, containing NF-κB-dependent pro-inflammatory senescence-associated secretome (SASP), was collected from senescent normal human fibroblasts and used to treat human epithelial breast cancer cells. It induced senescence and neuroendocrine transdifferentiation (NED), the latter being regulated by p53 and calcium in ER+ cells.