Research Paper Volume 15, Issue 8 pp 3035—3051

Figure 4. Reverse of drug-resistant cells caused by knockdown of TYRO3 expression. (A) Western blot assessing the effect of TYRO3-shRNA on H-DR and T-DR cells (B) Immunoblot result of H-DR and T-DR semi-quantified by ImageJ. (C) The viability of NC and TYRO3-KD H-DR cells treated with different concentrations of 5-Fu for 24 hours. (D) The IC50 of NC and TYRO3-KD cells treated with 5-Fu. (E) The viability of NC and TYRO3-KD T-DR cells treated with different concentrations of 5-Fu for 24 hours. (F) The IC50 of NC and TYRO3-KD cells treated with 5-Fu. Abbreviations: NC: negative control; KD: TYRO3-shRNA. ^*P < 0.05, ^**P < 0.01, ^***P < 0.001.