Research Paper Volume 15, Issue 8 pp 2999—3020

Figure 7. Rasgrf1 upregulation by the inhibition of miR-323-3p could improve the long-term potential impairment after CCH. (A) Field excitable postsynaptic potential was recorded and analyzed pre- and post- high frequency stimulation (pre-HFS recording as the baseline). (Con (n = 3), 2VO (n = 3), 2VO+miRNA-323-3p antagomir (n = 3), 2VO+ miRNA-323-3p antagomir NC (n = 3), 2VO+miRNA-323-3p antagomir+RasGRF1 siRNA (n = 3), 2VO+miRNA-323-3p antagomir + RasGRF1 scramble siRNA (n = 3)). (B) Relative field excitable postsynaptic potential and (C) population spike was analyzed over the baseline. ^**p < 0.01. The experiments were repeated three times.