Research Paper Volume 15, Issue 7 pp 2433—2449

Figure 3. Upregulation of SR increased total synaptic strength. (A) Schematic of PFC slice adapted from Paxinos [108] illustrating location of recording and position of stimulating and recording electrodes. The rectangular dash lined box indicates the area used for recording total and NMDAR-mediated synaptic responses. (B) Input-output curve of total-fEPSP in slices obtained from LV-SR (n = 8/4 slices/animals) and LV-GFP (n = 8/4 slices/animals) animals, plotting the mean SEM slope across animals relative to increasing stimulation intensities. p < 0.09 represents a tendency for treatment effect at higher stimulation intensities (20–40V).