Research Paper Volume 15, Issue 7 pp 2667—2688
Machine learning-based construction of immunogenic cell death-related score for improving prognosis and response to immunotherapy in melanoma
Figure 6. Sensitivity evaluation to anti-cancer therapy. (A) ICDscore of melanoma patients receiving immunotherapy in GSE35640, PUCH, Gide19, Liu19, VanAllen16, and Riaz17 cohorts. (B) Ratio of patients responding or not responding to immunotherapy in ICDscore-high and ICDscore-low subgroups of GSE35640, PUCH, Gide19, Liu19, VanAllen16, and Riaz17 cohorts. (C–F) Kaplan–Meier curves of OS in melanoma patients from ICDscore-high and ICDscore-low subgroups of VanAllen15 (C), PUCH (D), Liu19 (E), and Gide19 (G) cohorts. (G–N) Box plot showing a difference in the IC50 values of STF-62247 (G), Erlotinib (H), Rapamycin (I), Sunitinib (J), CGP-60474 (K), JW-7-52-1 (L), Roscovitine (M), CAL-101 (N) between ICDscore-high and ICDscore-low melanoma patients. Ns, not significant; *p < 0.05; **, p < 0.01.