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Research Paper Volume 15, Issue 6 pp 2097—2114
ADAMTS1 induces epithelial-mesenchymal transition pathway in non-small cell lung cancer by regulating TGF-β
Figure 5. ADAMTS1 promotes lung metastasis of tumor cells in mice. A549 (A–C) and H226 cells (D–F) with ADAMTS1 upregulation were used for constructing an in vivo lung metastasis model in nude mice. (A) HE staining was used for detecting the pathological changes in lungs from mice injected with A549 cells. (B) The gross image of the lung. (C) Protein expression of E-cadherin, N-cadherin, and Vimentin in the lung tissues of nude mice was detected using Western blot. (D) HE staining was used for detecting the pathological changes in the lung from mice injected with H226 cells. (E) The gross image of the lung. (F) Protein expression of E-cadherin, N-cadherin, and Vimentin in the lung tissues of nude mice was detected using Western blot. ***P<0.001 compared with the NC group. N=3.