Figure 5 — Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice

Research Paper|Volume 15, Issue 6|pp. 1977–2004

Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice

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Figure 5.Effect of Hsp22 on LPS-induced activation of NLRP3/Caspase-1/IL-1β pathways in BV2 Microglial Cells. (A) Cell Modeling Flowchart. (B) The protein band of Hsp22 and its expression (^*p < 0.05 vs. Control; ns: p > 0.05, LPS vs. LPS+OE-Control; ^#p < 0.05 vs. LPS+OE-Control). (C–E) The protein band of NLRP3, Caspase-1, IL-1β and its expression. (^**p < 0.01, ^*p < 0.05, ^**p < 0.01 vs. Control; ns: p > 0.05, LPS vs. LPS+OE-Control; ^##p < 0.01, ^#p < 0.05, ^##p < 0.01 vs. LPS+OE-Control).