Figure 3 — Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice

Research Paper|Volume 15, Issue 6|pp. 1977–2004

Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice

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Figure 3.Hsp22 overexpression pretreatment improves hippocampus tissue damage induced by LPS. (A) Histological analysis of Hippocampus tissue via HE staining (×200). (B) The degeneration rate of neurons in LPS group was higher than that in control group, and the difference was statistically significant (^***p < 0.005). The degeneration rate of neurons in LPS+Lv-Hsp22 group was lower than that in LPS+Lv-Hsp22-NC group, and the difference was statistically significant (^###p < 0.005). (C) Histological analysis of Hippocampus tissue via Nissl Staining (×200).