Figure 2 — Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice

Research Paper|Volume 15, Issue 6|pp. 1977–2004

Hsp22 pretreatment protects against LPS-induced hippocampal injury by alleviating neuroinflammation and apoptosis by regulating the NLRP3/Caspase1/IL-1β signaling pathway in mice

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Figure 2.Effect of Hsp22 on LPS-induced activation of NLRP3/Caspase-1/IL-1β pathways in the mice hippocampus tissue. The serum levels of IL-6, TNF-α and IL-1β. (A–C) (^**p < 0.01, ^***p < 0.005, ^***p < 0.005 vs. Control; ns: p > 0.05, LPS vs. LPS+Lv-Hsp22-NC; ^##p < 0.01, ^##p < 0.01, ^#p < 0.05 vs. LPS). The protein band of NLRP3, Caspase-1, IL-1β and its expression in the mice Hippocampus tissue (D–F). (^**p < 0.01, ^*p < 0.05, ^**p < 0.01 vs. Control; ns: p > 0.05, LPS vs. LPS+Lv-Hsp22-NC; ^#p < 0.05, ^###p < 0.005, ^#p < 0.05 vs. LPS+Lv-Hsp22-NC).