Research Paper Volume 15, Issue 8 pp 2920—2936
ESM1 promotes angiogenesis in colorectal cancer by activating PI3K/Akt/mTOR pathway, thus accelerating tumor progression
Figure 9. ESM1 shows an elevated expression in CRC cells and promotes the proliferation of CRC cells. (A, B) Relative protein expressions of p-PI3K, p-Akt, p-mTOR, MMP-2 and VEGF in ESM1-NC group, ESM1-mimic group, ESM1-NC + PI3K inhibitor group and ESM1-mimic + PI3K inhibitor group. (C, D) Expression of ESM1 in SW480 and SW620 cells. (E) Relative protein expression of ESM1 in CCD-841CoN, SW480 and SW620 cells. **p < 0.01, ns: p > 0.05.