Research Paper Volume 15, Issue 8 pp 2920—2936
ESM1 promotes angiogenesis in colorectal cancer by activating PI3K/Akt/mTOR pathway, thus accelerating tumor progression
Figure 8. ESM1 promotes the occurrence and development of tumors in nude mice. (A) SW480 cells transfected with ESM1-NC and ESM1-mimic are subcutaneously injected into nude mice to generate tumors. (B) Statistics for tumor volume in nude mice. (C) Immunofluorescence double stain result plot.green:CA199, red:CD31; (D) Compared with the ESM1-NC group, CA199 and CD31 were significantly higher in the ESM1-mimic group. *p < 0.05, **p < 0.01.