Research Paper Volume 15, Issue 5 pp 1496—1523

Figure 6. Construction and validation of prognostic risk model. (A) Alluvial diagram depicting the relationship of FAMcluster, genecluster, risk score (FAMscore) group and survival state. Boxplots of risk score in different FAMclusters (B) and geneclusters (C) Risk score distribution and scatter plots showing the risk score distribution and patient survival status in TCGA (D); Kaplan–Meier analysis of OS between the two groups in TCGA (E); ROC curves to predict the sensitivity and specificity of 1-, 3-, 5-year survival according the risk score in TCGA (F). Risk score distribution and scatter plots (G), Kaplan–Meier curves (H), ROC curves (I) of the risk model in ICGC cohort. The univariate (J) and multivariate (K) independent prognostic analysis of the model in TCGA cohort. Abbreviations: TCGA: the cancer genome atlas database; ICGC: International Cancer Genome Consortium; OS: overall survival; ROC: receiver operating characteristic.